i.Mune NEO [CE] is a quantitative in vitro diagnostic test to determine the percentages of lymphocyte subsets in newborn capillary whole blood specimens collected and dried on filter paper.
i.Mune NEO [CE] is suitable for epigenetic quantification of:
in dried blood spot (DBS) samples from newborns
A cohort of 250 apparently healthy newborns and 24 confirmed SCID and XLA cases was analyzed using epigenetic immune cell quantification of T-, B- and NK cells in dried blood spot samples2)
23 out of 24 confirmed SCID or XLA cases were correctly identified using the epigenetic immune cell quantification method.
Using combined TREC/KREC Analysis, 22 out of 24 cases were correctly identified2)
Epigenetic immune cell quantification identifies false-positive SCID screening cases (Blom et al., 2021)1)
**The above applications are currently tested in several studies