i.Mune™ TBNK (RUO)* is a quantitative test to determine the percentages and absolute** counts of human T-, B- and NK lymphocyte subsets in peripheral whole blood or in blood dried on filter paper.
Allows molecular quantification of:
Results are comparable to flow cytometry in blood1)
Comparison of immune cell quantification by epigenetic qPCR with flow cytometry in whole blood samples of healthy donors (n=25)
Top: Relative quantification (% cells); bottom: Absolute quantification (cells/μl)1)
Enables immune cell quantification using dried blood spots (DBS)1)
Method comparison of flow cytometry from whole blood with epigenetic qPCR from DBS in a HIV+ cohort (n=97). Relative quantification (% cells), only, for DBS samples1)
Quantification of T-/B- and NK lymphocytes can be useful for**:
*i.Mune TBNK is for research use, only and has not been registered as an IVD product and has not been approved or cleared by a regulatory authority.
**The above clinical applications have been established using technologies currently being employed in clinical laboratory routine (e.g. flow cytometry). Epimune has demonstrated equivalence of its epigenetic immune cell quantification method to flow cytometry (in whole blood) and the concordance of epigenetic immune cell quantification between whole blood and dried blood spots1)