Selected Literature (in progress)

Here we'll list a selection of publications relevant to immune cell quantification in different clinical applications (work in progress)

T-, B-, NK lymphocytes

• Baron U et al. Epigenetic immune cell counting in human blood samples for immunodiagnostics. Sci Transl Med. 2018 Aug 1;10(452).

Regulatory T-cells (Treg)

• Cepika AM et al. Tregopathies: Monogenic diseases resulting in regulatory T-cell deficiency. J Allergy Clin Immunol. 2018 Dec;142(6):1679-1695.
• Barth SD. Treg-Mediated Immune Tolerance and the Risk of Solid Cancers: Findings From EPIC-Heidelberg. J Natl Cancer Inst. 2015 Aug 22;107(11). 
• Türbachova I et al. The cellular ratio of immune tolerance (immunoCRIT) is a definite marker for aggressiveness of solid tumors and may explain tumor dissemination patterns. Epigenetics. 2013 Nov;8(11):1226-35.
• Barzaghi F et al. Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome. J Autoimmun. 2012 Feb;38(1):49-58.

T follicular helper (Tfh) cells

• Bokland SLM et al. Epigenetically quantified immune cells in salivary glands of Sjögren's syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology. Rheumatology (Oxford). 2020 Feb 1;59(2):335-343.

Th17 cells

• Burska AN et al. Quantifying circulating Th17 cells by qPCR: potential as diagnostic biomarker for rheumatoid arthritis. Rheumatology (Oxford). 2019 Nov 1;58(11):2015-2024.
• Singh A et al. Th17/Treg ratio derived using DNA methylation analysis is associated with the late phase asthmatic response. Allergy Asthma Clin Immunol. 2014 Jun 24;10(1)

MDSCs (myeloid-derived suppressor cells)

• Falck-Jones S et al., Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity. J Clin Invest. 2021 Jan 25:144734.
• Consonni FM et al. Myeloid-Derived Suppressor Cells: Ductile Targets in Disease. Front Immunol. 2019 May 3;10:949.