Myeloid-Derived Suppressor Cells (MDSC)

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that are characterized by the ability to suppress immune responses and expand during cancer, infection, and inflammatory diseases.


The role of MDSCs in solid tumors has been extensively characterized as pro-tumorigenic.


Conflicting roles have been reported in hematological malignancies […], which requires the balance between graft-versus leukemia (GVL) effects and immune tolerance.


(Source: Lv, 2019)

Role in Health and Disease