Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that are characterized by the ability to suppress immune responses and expand during
cancer, infection, and inflammatory diseases.
The role of MDSCs in solid tumors has been extensively characterized as pro-tumorigenic.
Conflicting roles have been reported in hematological malignancies […], which requires the balance between graft-versus leukemia (GVL) effects and immune tolerance.
(Source: Lv,
2019)
